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The amazing health benefits of resveratrol everyone should know

By Kim Crawford, M.D. Last updated: April 20, 2020
health benefits of resveratrol

The magic of resveratrol:health benefits of resveratrol

The health benefits of resveratrol are simply amazing. Resveratrol is just plain mandatory as a health supplement. In fact, it’s a prominent supplement in all of my disease-prevention recommendations.

It is found in abundance in red wine, and it’s highly soluble in alcohol. This means your body may absorb more of it from red wine than from other sources.

Consumers have clung to the notion that a glass of red wine will “do the trick” but have not really been educated about the rest of the story. In reality, the rest of that story is you’d need to drink about 100 glasses of red wine per day to get the health benefits of resveratrol supplements. I know, who knew, right?

Before I tell you the most effective source for your daily resveratrol, I’d like to review all of the things it will do for your health. So, please read on as there is much information to learn!

Where is the most concentrated form of resveratrol found?

Japanese knotweed is an excellent source of resveratrol, the chemical compound found in grapes. The difference is that Japanese knotweed contains high concentrations of trans-resveratrol, the active form of the compound most useful to the body. Japanese knotweed is quickly becoming the preferred source of resveratrol and is of course what we use in our resveratrol supplement. “File that” if you are shopping around and as always, don’t go “cheap,” go “best.” Of course, this means always know your source and purchase non-GMO, gluten free, pharma grade supplements or it’s quite honestly a waste of your money.

The general health benefits of resveratrol:

Resveratrol stops inflammation with a one-two knockout punch to stop your body from creating two different molecules known to trigger disease-causing internal inflammation—phospholipase D and sphingosine kinase. Resveratrol is also a potent antioxidant found in certain fruits, vegetables, and cocoa in small amounts. The science surrounding this compound is so compelling that it has become one of my all-time favorite antioxidant supplements. In fact, all of the specific health benefits I’ll discuss below are based mainly on resveratrol’s anti-inflammatory and anti-oxidant effects.

Resveratrol and inflammation:

Sphingosine kinase and phospholipase D  are, again, fatty molecules known to trigger inflammation. Chronic inflammation is not a beneficial bodily response, and in fact has been linked to numerous chronic diseases including heart disease, diabetes, Alzheimer’s and cancer. Resveratrol is also a potent anti-inflammatory nutrient in other ways, too. For example, it is a powerful inhibitor of cyclo-oxygenase-1 (COX-1), an enzyme that can promote inflammation which most people associated with being blocked by toxic NSAIDS (non-steroidal anti-inflammatory drugs). If you read my blog, you know how similarly useful curcumin AKA turmeric for pain and inflammation can be as well.

Besides counteracting inflammatory reactions, resveratrol promotes healthy immune function. Another example is in mice it can prevent herpes infections. Further, in humans, it can reverse the immune suppression caused by drinking alcohol.

Resveratrol and oxidative-stress:

Resveratrol is unique among antioxidants because it can cross the blood-brain barrier to help protect your brain and nervous system. I’ll go into this in detail, but here are just a few things this powerful polyphenol antioxidant will do:

It helps to prevent Alzheimer’s disease and has been shown to stave off short term memory loss progression. It inhibits the spread of cancer, especially prostate cancer. In addition, it helps to protect your cells from free radical damage. It keeps your heart healthy and improves elasticity in your blood vessels. It also lowers your blood pressure. Finally, it helps to normalize your anti-inflammatory response. With this in mind, let’s discuss some of the specific health benefits of resveratrol.

Resveratrol is anti-cancer!

Cancer-prevention and even cancer treatment is probably the most exciting area of resveratrol research (along with the brain; that info is coming up soon!) Resveratrol is the first natural substance which has solid evidence showing it blocks or stops many stages of cancer. Resveratrol not only helps to prevent cancer, but it’s also being proposed as an additional treatment; more about that to come. (Note: This is not something to try without checking with your doctor.)

Research Results

The number of studies has exploded, with the knowledge about this healthy polyphenol increasing with each scientific report. Resveratrol stops cancer in many diverse ways, from blocking estrogen and androgens to modulating genes. To explain, research shows resveratrol has the ability to penetrate deeply into the center of a cell’s nucleus. When it does this, it then allows the DNA to repair free radical damage that might otherwise contribute to cancerous growth.

In addition, resveratrol also helps cut down cancer cell reproduction, which reduces cancer cell growth. It also can make cancerous tumors more vulnerable to chemotherapy and radiotherapy. This is specifically why it is being “looked at” as an additional cancer therapy. It may end up being an important component in the cure for cancer. Many tumors develop resistance to chemotherapy over time. For this reason, resveratrol may very well be an effective  “chemo-sensitizer” that can help to overcome such resistance.

So far, cancers shown to respond favorably to resveratrol supplementation include multiple myeloma, lung cancer, acute myeloid and promyelocytic leukemia,  pancreatic cancer, and prostate cancer. Another of the health benefits of resveratrol involves the metastatic spread of cancer. Austrian researchers have done studies showing that resveratrol blocks the ability of cancer cells to metastasize to bone. The best results were seen for breast, pancreas, and kidney cancer. Colon and prostate cancers were inhibited but, in this one study, not quite as much.

In another study, resveratrol was also found to alleviate many of the severe side effects associated with conventional cancer treatments including fatigue, anxiety, weight loss, appetite loss, depression, and sleep disorders. According to the authors, all the evidence indicates these symptoms are because of dysregulation of inflammatory pathways. So, do you see? Indeed, it all goes back to inflammation and oxidative stress.

Resveratrol is great for your heart!

Nitric oxide is a critical component of heart and arterial function. Nitric oxide benefits include brain and vascular health. It allows blood vessels to “relax,” which increases/improves/enhances blood flow. In short, resveratrol increases nitric oxide.

Resveratrol also stops the proliferation of cells in blood vessels that narrow the arteries. It also is a bit of an anti-coagulant keeping blood cells from sticking together. Both of these functions are specifically important for the prevention of heart attacks. Resveratrol inhibits not only a clotting factor called thrombin but a slew of other stickiness-promoting factors. In addition, it down-regulates the production of CRP which is the bio-marker for coronary inflammation.

It also raises high-density lipoprotein (HDL) cholesterol, the “good” cholesterol. Additionally, it helps prevent artery damage caused by high levels of low-density lipoprotein (LDL) cholesterol, the “bad” cholesterol. To re-iterate, it lowers blood pressure due to the generation of extra nitric oxide.

Brain health and resveratrol:

In a 2010 study, resveratrol was found to suppress inflammatory effects in certain brain cells by suppressing production of natural pro-inflammatory chemicals. Resveratrol has also been found to improve cerebral blood flow to the brain. This has positive implications for vascular dementia as well as stroke. In fact, resveratrol users show a significant increase in functional connectivity of the hippocampus—the area of the brain involved in the formation, organization, and storage of memory.

BDNF (Brain-Derived Neurotrophic Factor) is an essential protein that influences brain health. BDNF influences a variety of functions including preventing death of existing brain cells, inducing the growth of new neurons (neurogenesis) and synapses, and supporting cognitive (thinking) function.

Low levels of BDNF have been linked to Alzheimer’s, accelerated aging, neurotransmitter dysfunction, obesity, depression, and more. Resveratrol, in doses of 150-200 mg/day, repeatedly show to increase BDNF. Researchers have concluded the increased expression of the BDNF mRNA may result in neuro-protective effects on the brain as well. Resveratrol has also been postulated to help prevent the buildup of amyloid and tau plaques which start as early as 20+ years before dementia symptoms.

Due to these reasons, resveratrol always makes it to my list of the best brain supplements you can buy. Specifically, it makes it to the supplements for memory and cognition list. Wow. What a healthy supplement, indeed!

Spinal Cord Injury Studies, Stroke and Resveratrol

Chinese researchers have found that resveratrol may help patients with spinal injuries and strokes, mainly by blocking the body’s inflammatory responses to the injuries. The verdict isn’t in, but it looks very good.

The really cool stuff- Anti-aging effects:

As a dietary supplement, resveratrol can turn on or off a large number of genes that are essential for lifespan and quality of life. Resveratrol’s pattern of gene regulation parallels that of caloric restriction (CR), the only other intervention known to extend healthy lifespan. CR or intermittent fasting takes a bit of willpower and lots of scheduling. On the positive side, one of the benefits of intermittent fasting is that it’s great for weight loss. However, as you’ll read below, resveratrol does its own little bit of magic for weight control. But first, back to the anti-aging effects. Resveratrol is convenient and is also safe for long-term use. The dosage for this and all other positive benefits is 150-200 mg per day.

Resveratrol stimulates the production of SIRT1, an enzymatic protein that blocks diseases by (for one thing) speeding up mitochondrial ATP meaning cellular energy production. Researchers have also figured out which gene allows resveratrol to produce SIRT1, and believe that some drugs currently in clinical trials may be able to provide the same anti-aging benefits. (I don’t know about you, but I’m just fine without the drugs! Thank you).

Because resveratrol appears to be so effective at warding off many diseases associated with aging, it is often referred to as a “fountain of youth supplement” that can extend lifespan.

Already, animal studies have shown that resveratrol helped overweight mice run farther and live about 20 percent longer too. It has also been found to increase the lifespan of human cells. Furthermore, the supplement seems to produce many similar benefits as exercise, and I believe that the combination of exercise plus resveratrol is additive.

Resveratrol and weight loss:

Going back to that SIRT1 pathway, one major function of SIRT1 is to prevent leptin resistance. Leptin is your principal hunger hormone which also regulates how efficiently your body stores fat. When you become overweight, your leptin goes up, and your fat cells become resistant to its hunger-suppressing effects. Studies demonstrate resveratrol is one of the nutrients which will augment SIRT1 and hence reduce leptin resistance and assist with weight loss. In fact, SIRT1 knowledge is the basis for the trendy sirtfood diet plan.

Blood sugar control:

In humans, high-calorie “all-American” inflammatory diets damage insulin regulation and therefore control of blood sugar. This can lead to insulin resistance and then to diabetes, cardiovascular disease, and fatty liver. Experiments have been performed, using mice on various diets. The high-calorie-fed mice developed blood sugar and insulin abnormalities, but resveratrol protected the other group of mice from blood sugar elevations by activating what is called the AMPK gene. This gene specifically manages insulin in mice.

In addition, the resveratrol group experienced a decline in glycated hemoglobin (HbA1c), which indicates improved blood sugar control. This supplement also helped with weight loss and suppression of food intake, implying even in this early study that this polyphenol might also help with weight management. Also, of course, we now know that studies looking at the SIRT1 pathway discussed above do indeed show resveratrol benefits include help with weight via leptin, insulin and likely adiponectin effects.

Topical Resveratrol and Skin Aging:

In recent years, resveratrol, in particular, has become the subject of intense interest due to its powerful antioxidant and anti-aging properties. It appears that resveratrol exerts its potent antioxidant effects by (1) scavenging existing free radicals and (2) preventing their formation.

Research specifically shows the antioxidant ability of topical resveratrol is very potent. In fact, it shows to be greater than that of vitamins E and C. One study demonstrated that resveratrol was 95% efficient at preventing the effects of harmful free radicals, compared to 65% for vitamin E and 37% for vitamin C. Hence, this magic polyphenol may turn out to be a great form of anti aging skin care.

Features of OUR resveratrol:

        Courtesy link

Resveratrol is made in a liquid filled vegetarian capsule using technology that guarantees purity, potency, and bioavailability.

The inclusion of resveratrol as a liquid rather than a powder or tablet ensures greater quality, absorption, activity, and benefit.

Oxygen is flushed from the capsule, and the ingredient is packed in an oxygen free environment so as to protect the ingredient from oxygen degradation.

Additionally, it is an all-vegetarian formula including a vegetable sourced capsule.

To point out, the vegetarian capsule technology offers quicker dissolution resulting in superior bioavailability meaning you will absorb and utilize our product to a greater extent.

The capsule is also impregnated with chlorophyllin, a chlorophyll derivative.  This protects the resveratrol from the degrading effects of light. It is encapsulated in conjunction with Grape Seed Extract and Quercetin; two other SIRT1 stimulating ingredients that enhance the health benefits of resveratrol.


  1. Unreal how great this stuff is and yours has even more good stuff in it-thanks for writing this Dr.Kim!

  2. that’s good, thanks for sharing,.. I think this is great blog

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